Abstract #0218

Characterization of brain susceptibility changes in post-hospitalisation COVID-19 patients at 7 Tesla

Catarina Rua^1,2, Christopher T Rodgers^2,3, Virginia F J Newcombe^2,4, Anne Manktelow⁴, Doris A Chatfield⁴, Stephen J Sawcer³, Joanne G Outtrim⁴, Victoria C Lupson², Emmanuel A Stamatakis^2,3,4, Guy B Williams^2,3, William T Clarke⁵, Karen D Ersche^6,7, Kyle Pattinson⁵, Edward T Bullmore^6,7, David K Menon^2,4,8, and James B Rowe^1,9

¹Department of Clinical Neurosciences and University of Cambridge Centre for Parkinson-plus, University of Cambridge, Cambridge, United Kingdom, ²Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom, ³Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, ⁴Division of Anaesthesia, University of Cambridge, Cambridge, United Kingdom, ⁵Welcome Centre for Integrative Neuroimaging (FMRIB), University of Oxford, Oxford, United Kingdom, ⁶Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom, ⁷Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom, ⁸on behalf of the Cambridge NeuroCOVID group (www.wbic.cam.ac.uk/neuro-covid/) and the CITIID-NIHR COVID-19 BioResource Collaboration, Cambridge, United Kingdom, ⁹Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom

Patients hospitalized with the new coronavirus disease (COVID-19) have shown severe changes in the central nervous system (CNS), particularly microhaemorrhages and encephalitis. However, long-term effects on the CNS haven not yet been fully characterised. In this study we scanned a group of 14 recently hospitalized COVID-19 patients at ultra-high field (7T) and analysed the microstructural changes measured by quantitative susceptibility mapping (QSM) from both subcortical nuclei and brainstem, which are thought to be targeted by the virus.

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