Abstract #0217

Examining cerebral blood flow in adults with COVID-19

William S.H. Kim^1,2, Xiang Ji², J. Jean Chen^1,3, Asaf Gilboa³, Eugenie Roudaia³, Allison Sekuler³, Aravinthan Jegatheesan⁴, Mario Masellis², Benjamin Lam², Robert Fowler⁵, Chris Heyn², Sandra E. Black², Simon J. Graham^1,4, and Bradley J. MacIntosh^1,2

¹Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada, ³Rotman Research Institute, Toronto, ON, Canada, ⁴Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, ⁵Evaluative Clinical Sciences, Trauma, Emergency & Critical Care, Sunnybrook Research Institute, Toronto, ON, Canada

The relationship between coronavirus disease 2019 (COVID-19) and cerebral blood flow (CBF) is not well understood. Here, we report on CBF measured by pseudo-continuous arterial spin labeling among adults that weeks prior had experienced flu-like symptoms with either a positive or negative COVID-19 diagnosis. Recruitment is ongoing, but at present we report no group differences in CBF across brain grey matter. However, subsequent regional analyses point to possible CBF abnormalities in those with a positive COVID-19 diagnosis.

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