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Abstract #0217

Examining cerebral blood flow in adults with COVID-19

William S.H. Kim1,2, Xiang Ji2, J. Jean Chen1,3, Asaf Gilboa3, Eugenie Roudaia3, Allison Sekuler3, Aravinthan Jegatheesan4, Mario Masellis2, Benjamin Lam2, Robert Fowler5, Chris Heyn2, Sandra E. Black2, Simon J. Graham1,4, and Bradley J. MacIntosh1,2
1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada, 3Rotman Research Institute, Toronto, ON, Canada, 4Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, 5Evaluative Clinical Sciences, Trauma, Emergency & Critical Care, Sunnybrook Research Institute, Toronto, ON, Canada

The relationship between coronavirus disease 2019 (COVID-19) and cerebral blood flow (CBF) is not well understood. Here, we report on CBF measured by pseudo-continuous arterial spin labeling among adults that weeks prior had experienced flu-like symptoms with either a positive or negative COVID-19 diagnosis. Recruitment is ongoing, but at present we report no group differences in CBF across brain grey matter. However, subsequent regional analyses point to possible CBF abnormalities in those with a positive COVID-19 diagnosis.

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