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Abstract #0216

Ex vivo quantitative MR characterization of brain lesions induced by SARS-COV-2 infection

Mathieu David Santin1,2, Isabelle Plu3, Lydia Chougar1,2,3, Nadya Pyatigorskaya1,2,3, Roberto Toro4, Stéphane Lehéricy1,2,3, and Danielle Seilhean2,3
1Center for NeuroImaging Research - CENIR, Paris Brain Institute - ICM, Paris, France, 2ICM, Sorbonne University, UPMC Univ Paris 06, Inserm U1127, CNRS UMR 7225, Paris, France, 3Hôpital Pitié-Salpêtrière, AP-HP, Paris, France, 4Institut Pasteur, Paris, France

Our study aims to link ex vivo brain MRI signal abnormalities with neuropathological findings relative to the SARS-CoV-2 infection. MRI offers a “big picture” image on the whole organ compared to histology alone, which can be limited to blindly sampled small sections, when recent imagery is not available. The objective is to characterize the brain lesions linked to the viral infection. Our project should produce a new description of the anatomical structures affected by the infection in the central nervous system, and in particular those related to the brain vascular system.

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