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Abstract #0231

Deuterium Echo-Planar Spectroscopic Imaging (DEPSI) to Dynamically Monitor Deuterated Glucose in the Liver at 7T

Kyung Min Nam1, Ayhan Gursan1, Alex Bhogal1, Jannie Wijnen1, Dennis Klomp1, Jeanine Prompers1, and Arjan D. Hendriks1
1University of Medical Center Utrecht, Utrecht, Netherlands

Deuterium Echo-Planar Spectroscopic Imaging (DEPSI) is proposed as a way to increase the spatial and temporal resolution of deuterium metabolic imaging (DMI) at 7T. Typically, DMI uses traditional, slow MRSI sequences, which cannot capture rapid dynamic metabolic processes in large organs with sufficient spatial and/or temporal resolution. With DEPSI, in vivo glucose metabolism of the liver could be monitored after intake of [6,6′-2H2]-glucose with 20 mm nominal voxel size, full liver coverage, and a scan time of less than 10 minutes. DEPSI was combined with Hamming weighted acquisition in the phase encoding directions to maximize SNR.

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