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Abstract #0232

Deuterium metabolic imaging (DMI) of glucose metabolism in pregnant preeclamptic mice at 15.2 tesla.

Stefan Markovic1, Tangi Roussel2, Michal Neeman3, and Lucio Frydman1
1Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, 2Center for Magnetic Resonance in Biology and Medicine, Marseille, France, 3Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

Deuterium Metabolic Imaging (DMI) was used to follow metabolism in wildtype and l-NAME induced preeclamptic pregnant mice, after intravenous administration of 2H6,6’-glucose. Maps for 2H6,6’-glucose and its metabolic products 2H3,3’-lactate and 2H-water were measured over 2 hours by 2H CSI at 15.2 tesla. 2H-water was generated as main metabolic product in fetoplacental units; placentas and fetal organs also generated 2H3,3’-lactate, but this was not detected in other maternal organs. Lactate levels were more elevated and its clearance was slower in preeclamptic fetuses than in healthy controls. DMI thus may aid in development and monitoring of future intervention for early preeclampsia.

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