Abstract #0232

Deuterium metabolic imaging (DMI) of glucose metabolism in pregnant preeclamptic mice at 15.2 tesla.

Stefan Markovic¹, Tangi Roussel², Michal Neeman³, and Lucio Frydman¹

¹Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, ²Center for Magnetic Resonance in Biology and Medicine, Marseille, France, ³Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

Deuterium Metabolic Imaging (DMI) was used to follow metabolism in wildtype and l-NAME induced preeclamptic pregnant mice, after intravenous administration of ²H_6,6’-glucose. Maps for ²H_6,6’-glucose and its metabolic products ²H_3,3’-lactate and ²H-water were measured over 2 hours by ²H CSI at 15.2 tesla. ²H-water was generated as main metabolic product in fetoplacental units; placentas and fetal organs also generated ²H_3,3’-lactate, but this was not detected in other maternal organs. Lactate levels were more elevated and its clearance was slower in preeclamptic fetuses than in healthy controls. DMI thus may aid in development and monitoring of future intervention for early preeclampsia.

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