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Abstract #0233

Hyperpolarized [2-13C]Pyruvate Molecular Imaging with Whole Brain Coverage

Yaewon Kim1, Brian T. Chung1, Jeremy W. Gordon1, Adam W. Autry1, Chou T. Tan2, Chris Suszczynski2, Susan M. Chang3, Yan Li1, Duan Xu1, and Daniel B. Vigneron1,3
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States, 2ISOTEC Stable Isotope Division, MilliporeSigma, Merck KGaA, Miamisburg, OH, United States, 3Department of Neurological Surgery, University of California, San Francisco, CA, United States

Hyperpolarized (HP) [2-13C]pyruvate MRI has great clinical potential for monitoring pyruvate-to-glutamate conversions through the TCA cycle in addition to pyruvate-to-lactate glycolytic metabolism. This new method for human molecular imaging has enabled whole brain acquisitions with sufficient signal-to-noise. Using a specialized multi-slice EPI sequence, volumetric, dynamic images of HP [2-13C]pyruvate and its downstream metabolites [5-13C]glutamate and [2-13C]lactate were acquired from healthy brain volunteers. The downfield and upfield lactate signals were acquired separately with no artifacts arising from J-coupling were observed. This work demonstrated the capability of volumetric and dynamic [2-13C]pyruvate EPI to interrogate both glycolytic and oxidative cerebral energy metabolism simultaneously.

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