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Abstract #0235

High-resolution 3D Phosphorus Metabolic Imaging of the Human Brain at 7T using SPICE

Hannes Michel Wiesner1, Rong Guo2,3, Yudu Li2,3, Yibo Zhao2,3, Zhi-Pei Liang2,3, Xiao-Hong Zhu1, and Wei Chen1
1CMRR, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 2Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Departments of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States

In vivo 31P MRS imaging (MRSI) is unique to study brain energy metabolism including ATPase and creatine kinase metabolic rates, and the NAD redox ratio especially at ultrahigh field (UHF) with significant improvements in detection sensitivity and spectral resolution. Nevertheless it is still challenging to achieve high spatial resolution even at UHF, owing to extremely low concentration of phosphorus metabolites. In this study, we employed the subspace‐based image reconstruction method called SPICE to largely reduce spectral noise and increase the signal-to-noise ratio (SNR) for achieving high-resolution 3D 31P MRSI covering the entire human brain at 7T.

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