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Abstract #0242

Deuterium metabolic imaging (DMI) of Water, Glucose and Lactate using spectroscopic multi-echo bSSFP: A higher Signal to Noise Approach

Dana C. Peters1, Stefan Markovic2, Qingjia Bao2, Dina Preise2, Keren Sasson2, Lilach Agemy2, Avigdor Scherz2, and Lucio Frydman2
1Radiology and Biomed Eng., Yale University, New Haven, CT, United States, 2Weizmann Institute of Science, Rehovot, Israel

Deuterium metabolic imaging (DMI) maps the individual in vivo fate of 2H-enriched metabolites. Upon injecting 2H6,6’-glucose, DMI images a 2H-water peak, and a small but diagnostic 2H3,3’-lactate signature, highlighting tumors and their aberrant metabolism. DMI faces major sensitivity challenges, that can be alleviated by a multi-echo balanced SSFP approach. When suitably tuned, multi-echo bSSFP yields good spectral isolation of all metabolites, and thanks to the relatively large T2/T1 ratios of deuterated compounds, several-fold increases in SNR vs. chemical shift imaging are then obtained. This is demonstrated in phantoms, and in in vivo mice studies of orthotopic pancreatic tumors.

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