Abstract #0243

Detection of ionic bonding using IMMOBILISE MRI and theoretical description of the relayed NOE transfer mechanism

Yang Zhou¹, Peter van Zijl^2,3, Chongxue Bie^2,3,4, Jiadi Xu^2,3, Xin Liu¹, and Nirbhay N. Yadav^2,3

¹Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Shenzhen, China, ²The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁴Department of Information Science and Technology, Northwest University, Xian, China

Saturation transfer MRI has previously been applied to study transient molecular binding using the IMMOBILISE MRI approach, yet the multiple mechanisms of magnetization transfer during such binding are still under investigation. We studied electrostatic-interaction-mediated molecular binding of small substrates (choline and arginine) to ion-exchange column media. A theoretical model using relayed NOEs to exchangeable protons in the bound substrate is proposed to quantitatively describe the saturation transfer during such binding.

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