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Abstract #0245

Improved T2' Mapping in Simultaneous Neurometabolic and Oxygenation Imaging Experiments

Tianxiao Zhang1, Rong Guo2,3, Yudu Li2,3, Yibo Zhao2,3, Zhi-Pei Liang2,3, and Yao Li1
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States

Simultaneous MRSI and T2* mapping has been demonstrated recently using SPICE. With a T2 map, T2' values could be calculated, which reflects tissue oxygenation. However, the accuracy of T2* and T2 measurements suffers from system imperfections. In this work, we improved T2' mapping by overcoming signal dephasing in T2* mapping and estimation bias in T2 mapping. The signal dephasing in T2* caused by B0 inhomogeneity was corrected utilizing high-resolution field map and pre-learned subspaces, and the estimation bias in T2 caused by B1+ inhomogeneity was corrected with a dictionary-based estimation. The proposed method provided improved T2' mapping in SPICE experiments.

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