Abstract #0245

Improved T2' Mapping in Simultaneous Neurometabolic and Oxygenation Imaging Experiments

Tianxiao Zhang¹, Rong Guo^2,3, Yudu Li^2,3, Yibo Zhao^2,3, Zhi-Pei Liang^2,3, and Yao Li¹

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States

Simultaneous MRSI and T₂* mapping has been demonstrated recently using SPICE. With a T₂ map, T₂' values could be calculated, which reflects tissue oxygenation. However, the accuracy of T₂* and T₂ measurements suffers from system imperfections. In this work, we improved T₂' mapping by overcoming signal dephasing in T₂* mapping and estimation bias in T₂ mapping. The signal dephasing in T₂* caused by B₀ inhomogeneity was corrected utilizing high-resolution field map and pre-learned subspaces, and the estimation bias in T₂ caused by B₁⁺inhomogeneity was corrected with a dictionary-based estimation. The proposed method provided improved T₂' mapping in SPICE experiments.

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