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Abstract #0246

Evaluation of an Iron-Oxide Nanoparticle Contrast Agent for Vascular Suppression in Magnetic Resonance Neurography

Sophie Queler1, Ek Tsoon Tan1, Martin Prince2, John Carrino1, and Darryl Sneag1
1Radiology and Imaging, Hospital for Special Surgery, New York, NY, United States, 2Weill Cornell Medicine, New York, NY, United States

In this study, we investigated the use of ferumoxytol, an iron-oxide nanoparticle, for vascular signal suppression in 3 Tesla magnetic resonance neurography of the brachial plexus. A 3D, T2-weighted STIR sequence was prospectively acquired of 19 normal brachial plexi in 10 volunteers (1 unilateral; 9 bilateral) before and after ferumoxytol infusion. Independent assessment of anonymized exams by two radiologists demonstrated overall improved vascular suppression as well as improved visualization of the suprascapular nerve with increased diagnostic confidence. Improvements in nerve-, fat-, and blood-to-muscle contrast were supported by signal simulations.

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