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Abstract #0250

Calibrationless B1 Mapping for Accurate Macromolecular Proton Fraction Mapping Using Relaxometry Constraints

Alexey Samsonov1
1University of Wisconsin-Madison, Madison, WI, United States

Macromolecular proton fraction (MPF) is an established myelin marker with confirmed clinical relevance, but with sensitivity to technological variations such as B1 field errors. We propose a method to derive B1 map for MPF correction from MPF data itself. The method is based on standard two-pool MT formalism enhanced with improved relaxometry constraints.

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