Abstract #0262

The aging quantitative brain: a multiparametric qMRI study

Ana-Maria Oros-Peusquens*¹, Jonas Kielmann*¹, and N. Jon Shah^1,2,3,4

¹INM-4, Research Centre Juelich, Juelich, Germany, ²Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany, ³INM-11, JARA, Research Centre Juelich, Juelich, Germany, ⁴Department of Neurology, RWTH Aachen University, Aachen, Germany

Quantitative MRI parameters are determined by the properties of tissue on a microscopic scale and can be expected to reflect microstructural changes created by aging. Here, we investigate a multiparametric qMRI signature of healthy ageing on 26 healthy volunteers, characterised in a high-dimensional parametric space (water content, relaxometry, qMT). Changes with age in the mean values and correlations between parameters are observed and interpreted.

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