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Abstract #0263

Alterations in dynamic functional connectivity in individuals with subjective cognitive decline

Qian Chen1, Jiaming Lu2, Xin Zhang2, Jilei Zhang3, and Bing Zhang1
1Department of Radiology, Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China, 2Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China, 3Philips Healthcare, Shanghai, China

Subjective cognitive decline (SCD) is considered a clinically-based approach for the detection of potential Alzheimer’s disease patients. We observed altered temporal properties of fractional windows, mean dwell time, and the number of transitions by dynamic functional connectivity (DFC) analysis in SCD individuals compared to the control subjects. The altered DFC parameters showed significant associations with cognitive performance. Our findings shed light on the role of DFC in the early detection of subjects with potential Alzheimer’s disease, and the alterations in DFC may suggest the neural basis underlying early cognitive decline in the SCD stage.

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