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Abstract #0264

Age-related alterations in cortical myelin profile using the Human Connectome Project Aging dataset

Yu Veronica Sui1 and Mariana Lazar1
1Radiology, New York University Grossman School of Medicine, New York, NY, United States

Demyelination is recognized as a major process in both normal aging and neurodegenerative diseases. Using the Human Connectome Project Aging dataset, we investigated intracortical demyelination in normal aging using T1w/T2w maps. To capture the fine changes across cortical layers, we employed a surface-based approach in contrast to the commonly used volumetric approach by constructing a cortical myelin profile for each region, which was then quantified using a nonlinearity index. We showed that the nonlinearity of cortical myelin profile exhibits a steeper decline with aging than cortical thickness and therefore presents the potential of a unique marker of age-related microstructural changes.

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