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Abstract #0266

Association of age-related neuropathologies with shape of subcortical structures in a large community cohort of older adults

Nazanin Makkinejad1, Ashish A. Tamhane2, David A. Bennett2, Julie A. Schneider2, Boris Gutman1, and Konstantinos Arfanakis1,2
1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States

Age-related neuropathologies have devastating effects on subcortical brain structures. MRI can be used to explore patterns of atrophy associated with various diseases, however, definitive diagnosis of age-related neuropathologies is only possible at autopsy. Therefore, this work combined ex-vivo MRI and detailed pathologic assessment (gold standard) in a large (N=814) community cohort of older adults to investigate the link between age-related neuropathologies and the shape of different subcortical brain structures. The resulting patterns of deformation may contribute towards development or enhancement of in-vivo classifiers of these neuropathologies.

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