Abstract #0266

Association of age-related neuropathologies with shape of subcortical structures in a large community cohort of older adults

Nazanin Makkinejad¹, Ashish A. Tamhane², David A. Bennett², Julie A. Schneider², Boris Gutman¹, and Konstantinos Arfanakis^1,2

¹Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States

Age-related neuropathologies have devastating effects on subcortical brain structures. MRI can be used to explore patterns of atrophy associated with various diseases, however, definitive diagnosis of age-related neuropathologies is only possible at autopsy. Therefore, this work combined ex-vivo MRI and detailed pathologic assessment (gold standard) in a large (N=814) community cohort of older adults to investigate the link between age-related neuropathologies and the shape of different subcortical brain structures. The resulting patterns of deformation may contribute towards development or enhancement of in-vivo classifiers of these neuropathologies.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.