Abstract #0267

Assessment of Cerebrovascular Disease and White Matter Neurite Density in Alzheimer’s Disease

Grant S Roberts¹, Leonardo A Rivera-Rivera², Kevin M Johnson^1,3, Sterling C Johnson², Douglas C Dean III^1,4, Andrew L Alexander^1,5, Oliver Wieben¹, and Laura B Eisenmenger³

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Medicine, University of Wisconsin - Madison, Madison, WI, United States, ³Radiology, University of Wisconsin - Madison, Madison, WI, United States, ⁴Pediatrics, University of Wisconsin - Madison, Madison, WI, United States, ⁵Psychiatry, University of Wisconsin - Madison, Madison, WI, United States

White matter (WM) microstructural alterations have been shown to occur in Alzheimer’s disease (AD) and may be partially mediated by cerebrovascular disease (CVD). The objective of this study is to use neurite orientation dispersion and density imaging (NODDI) to assess differences in neurite density (NDI) and its relationship to measures of CVD from 4D flow MRI in cognitively normal (CN) and AD subjects. Our results showed differences in NDI between groups in various WM tracts and found correlations between NDI and cerebral blood flow in CN subjects in several WM structures.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.