Abstract #0267

Assessment of Cerebrovascular Disease and White Matter Neurite Density in Alzheimer’s Disease

Grant S Roberts¹, Leonardo A Rivera-Rivera², Kevin M Johnson^1,3, Sterling C Johnson², Douglas C Dean III^1,4, Andrew L Alexander^1,5, Oliver Wieben¹, and Laura B Eisenmenger³

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Medicine, University of Wisconsin - Madison, Madison, WI, United States, ³Radiology, University of Wisconsin - Madison, Madison, WI, United States, ⁴Pediatrics, University of Wisconsin - Madison, Madison, WI, United States, ⁵Psychiatry, University of Wisconsin - Madison, Madison, WI, United States

White matter (WM) microstructural alterations have been shown to occur in Alzheimer’s disease (AD) and may be partially mediated by cerebrovascular disease (CVD). The objective of this study is to use neurite orientation dispersion and density imaging (NODDI) to assess differences in neurite density (NDI) and its relationship to measures of CVD from 4D flow MRI in cognitively normal (CN) and AD subjects. Our results showed differences in NDI between groups in various WM tracts and found correlations between NDI and cerebral blood flow in CN subjects in several WM structures.

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