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Abstract #0285

GABA measurement at 7T: short-TE or MEGA editing?

Song-I Lim1,2 and Lijing Xin1,2
1CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 2Animal Imaging and Technology, EPFL, Lausanne, Switzerland

The purpose of the study is to compare short-TE and MEGA editing methods and verify reproducibility of GABA measurement in the motor cortex at 7T. The measured average GABA/Cr and GABA/NAA ratios were 0.121 ± 0.034 and 0.057 ± 0.019 respectively for short-TE sSPECIAL measurement and 0.083 ± 0.014 and 0.052 ± 0.008 respectively for MEGA-sSPECIAL sequence. 6 healthy volunteers were scanned two times and average coefficient of variances were 21.2 ± 11.8 % for short-TE measurement and 4.5 ± 3.9 for MEGA-sSPECIAL sequence.

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