Brain lactate compartmentation is an important but debated neuroscience question. By assessing local microstructure where lactate is diffusing in, diffusion-weighted MRS has unique potential to non-invasively assess lactate compartmentation. We propose to increase lactate signal using selective pulses (SP) to cancel J-modulation. We compare lactate signal behavior in diffusion-weighted experiments performed in vivo, using either spin echo or stimulated echo sequence relying on selective pulses. We verify here that the signal increases in both cases, compared to conventional cases using broad pulses. Spin echo using SP appears the most valuable option to measure lactate diffusion at high b-values.
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