We propose a method to calculate T2* values of brain metabolites from a series of time-shifted datasets obtained from a single 1H magnetic resonance spectroscopy acquisition. T2* values from five brain metabolites were measured in the posterior cingulate cortex. Robust T2* values were obtained for all five metabolites, including J-coupled metabolites such as glutamate and myo-inositol, for which T2* estimation is otherwise not possible. We show in a subsequent reproducibility study that the water linewidth within the same volume can be used to account for variability in local B0 inhomogeneity and reduce the associated variability across measurements.
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