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Abstract #0288

T2* of human brain metabolites estimated from a single proton MRS acquisition

ChloƩ Najac1, Marjolein Bulk1, Hermien E. Kan1, Andrew G. Webb1, and Itamar Ronen1
1C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

We propose a method to calculate T2* values of brain metabolites from a series of time-shifted datasets obtained from a single 1H magnetic resonance spectroscopy acquisition. T2* values from five brain metabolites were measured in the posterior cingulate cortex. Robust T2* values were obtained for all five metabolites, including J-coupled metabolites such as glutamate and myo-inositol, for which T2* estimation is otherwise not possible. We show in a subsequent reproducibility study that the water linewidth within the same volume can be used to account for variability in local B0 inhomogeneity and reduce the associated variability across measurements.

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