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Abstract #0291

Multi-modal, multi-resolution imaging of a single mouse brain

Sean Foxley1, Vandana Sampathkumar1, Vincent De Andrade2, Scott Trinkle1, Anstasia Sorokina1, Katrina Norwood1, Patrick La Riviere1, and Narayanan Kasthuri1
1University of Chicago, Chicago, IL, United States, 2Advanced Photon Source, Argonne National Laboratory, Lamont, IL, United States

Mammalian neurons operate at length scales spanning many orders of magnitude; micron-scale-diameter myelinated axons project millimeters across brain regions, forming nanometer scale synapses. Capturing these disparately sized anatomical features requires imaging samples with multiple independent imaging modalities. Directly correlating features across modalities requires that all imaging is performed in the same brain. Here, we imaged the same postmortem mouse brain over five orders of spatial resolution using MRI, synchrotron x-ray tomography (μCT), and electron microscopy. This pipeline provides an unprecedented look across a single brain's multi-scaled organization and a vehicle for studying the brain’s multi-scaled pathologies.

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