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Abstract #0292

Pre- and post-neonatal in vivo DTI on mice: Targeting brain microstructures at 15.2T

Odélia Jacqueline Chitrit1, Qingjia Bao1, Maxime Yon1, and Lucio Frydman1
1Department of Chemical and Biological Physics, Weizmann institute of Science, Rehovot, Israel

DTI is a well-established technique for mapping brain microstructure. Brain’s microstructural features derive from white matter and change over the course of maturation; hence methods that can acquire DTI in utero and immediately post-partum, are of interest. The present study explores the use of a customized 3D phase-encoded Spatiotemporal Encoding (SPEN) MRI approach that can be used to overcome the motional and susceptibility challenges arising in such instances, delivering quality DTI volumetric data at 15.2T. Maps of ADC, MDD and FA could thus be collected for mice fetal brains in utero, as well as within the first week post-partum.

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