DTI is a well-established technique for mapping brain microstructure. Brain’s microstructural features derive from white matter and change over the course of maturation; hence methods that can acquire DTI in utero and immediately post-partum, are of interest. The present study explores the use of a customized 3D phase-encoded Spatiotemporal Encoding (SPEN) MRI approach that can be used to overcome the motional and susceptibility challenges arising in such instances, delivering quality DTI volumetric data at 15.2T. Maps of ADC, MDD and FA could thus be collected for mice fetal brains in utero, as well as within the first week post-partum.
This abstract and the presentation materials are available to members only; a login is required.