Abstract #0293

Measuring apparent water exchange using Filter Exchange Imaging and diffusion time dependent kurtosis imaging in post-mortem mouse brains

Chenyang Li^1,2, Els Fieremans¹, Dmitry S. Novikov¹, Yulin Ge¹, and Jiangyang Zhang¹

¹Department of Radiology, Center for Biomedical Imaging, NYU Grossman School of Medicine, New York, NY, United States, ²Vilcek Institute of Graduate Biomedical Sciences, NYU Grossman School of Medicine, New York, NY, United States

Filter exchange imaging (FEXI) and diffusion time dependent diffusion kurtosis imaging (DKI(t)) are two techniques that are sensitive to water exchange between tissue compartments. However, built on different theoretical frameworks and models, many questions remain on the interpretations of FEXI and (DKI(t)) results in the brain. In this study, we measured water exchange effects in post-mortem mouse brains using FEXI and (DKI(t)) and observed a correlation between them, suggesting that they are sensitive to similar exchange processes.

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