Abstract #0296

g-Ratio in the common marmoset: a comparison across different myelin-sensitive MRI metrics with b-tensor encoded diffusion

Christopher D Rowley^1,2, Ilana R Leppert², Jennifer SW Campbell², Filip Szczepankiewicz^3,4, Stephen Nuara⁵, Markus Nilsson³, G Bruce Pike⁶, and Christine L Tardif^1,2,7

¹Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, ²McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, ³Diagnostic Radiology, Clinical Sciences Lund, Lund University, Lund, Sweden, ⁴Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, ⁵Comparative Medicine and Animal Resources Center, McGill University, Montreal, QC, Canada, ⁶Hotchkiss Brain Institute and Departments of Radiology and Clinical Neuroscience, University of Calgary, Calgary, AB, Canada, ⁷Department of Biomedical Engineering, McGill University, Montreal, QC, Canada

The g-ratio quantifies the relative thickness of the myelin sheath and can be estimated from myelin volume fraction (MVF) and axonal volume fraction (AVF) maps. The best MRI methods for deriving these metrics are still under investigation. This study examines the use of inhomogeneous magnetization transfer (ihMT_sat) along with other myelin-sensitive metrics, and diffusion MRI with b-tensor encoding for calculating the g-ratio in a marmoset brain. We find that while the different myelin-sensitive metrics and diffusion microstructural models produce different MVF and AVF maps, the g-ratio values follow similar trends across the white matter.

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