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Abstract #0299

Column-based cortical depth analysis of the diffusion anisotropy in submillimeter whole-brain DTI of the human gray matter

Yixin Ma1,2, Trong-Kha Truong1,2, Iain P. Bruce1, Chun-Hung Yeh3, Jeffrey R. Petrella1,2, and Allen W. Song1,2
1Brain Imaging and Analysis Center, Duke University, Durham, NC, United States, 2Medical Physics Graduate Program, Duke University, Durham, NC, United States, 3Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital, Taoyuan, Taiwan

High-resolution diffusion tensor imaging (DTI) can noninvasively probe the microstructural integrity of cortical gray matter in vivo. We propose a column-based method that samples submillimeter isotropic whole-brain DTI data along radially oriented cortical columns to achieve a quantitative analysis of the fractional anisotropy and radiality index dependence on the cortical depth, curvature, and brain regions across the whole brain. This method is robust across repeated scans and healthy subjects, and can capture characteristic diffusion anisotropy and radiality patterns in the cortical gray matter, potentially providing quantitative biomarkers for various neurological disorders.

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