Abstract #0300

Ex-vivo whole human brain high b-value diffusion MRI at 550 micron with a 3T Connectom scanner

Gabriel Ramos-Llordén¹, Chiara Maffei¹, Qiyuan Tian¹, Berkin Bilgic^1,2, Thomas Witzel³, Boris Keil⁴, Anatasia Yendiki¹, and Susie Huang^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Masachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, ²Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, ³Q Bio Inc, San Carlos, CA, United States, ⁴Institute of Medical Physics and Radiation Protection, Mittelhessen University of Applied Sciences, Giessen, Germany

We demonstrate high quality, high b-value diffusion MRI (up to 10 000 s / mm²) in an ex-vivo human brain at ultra-high spatial resolution (550 micrometer). The high signal quality allows us to obtain high diffusion contrast and delineate fine structures that cannot be resolved within in vivo acquisitions. We present DTI and DKI results of the whole brain, show diffusivity on the primary somatosensory, auditory, and visual cortex areas as well as illustrate tractography of the hippocampus and thalamus structures, revealing internal connectivity at a high level of detail.

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