Abstract #0314

Macromolecular proton fraction mapping based on spin-lock for the non-invasive diagnosis of early stage liver fibrosis

Jian Hou¹, Vincent Wai-Sun Wong², Grace Lai-Hung Wong², Baiyan Jiang¹, Yi-Xiang Wang¹, Anthony Wing-Hung Chan³, Winnie Chiu-Wing Chu¹, and Weitian Chen¹

¹Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ³Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong

Liver fibrosis is characterized by excessive accumulation of extracellular matrix proteins, such as collagen. Macromolecular Proton Fraction (MPF) is an indicator of the relative amount of macromolecular content. It was reported recently that MPF map can be obtained based on spin-lock (MPF-SL). In this work, we investigated the diagnostic value of MPF-SL for detecting early stage liver fibrosis on a clinical study.

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