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Abstract #0318

Repeatability of Liver Apparent Diffusion Coefficient Measurement Using Free-Breathing Diffusion-Weighted Propeller Echo-Planar Imaging

Hing-Chiu Chang1, Lu Wang1, Guangtao Chen1, Liyuan Liang1, Keith Wan-Hang Chiu1, Yi-Jui Liu2, Chun-Jung Juan3,4,5, and Hsiao-Wen Chung6,7
1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, 3Department of Medical Imaging, China Medical University Hsinchu Hospital, Hsinchu, Taiwan, 4Department of Radiology, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan, 5Department of Medical Imaging, China Medical University Hospital, Taichung, Taiwan, 6Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, 7Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan

The current limitations of liver DWI mainly relate to the image quality and the repeatability/reproducibility of ADC measurement using single-shot DW echo-planar imaging (DW-EPI). The discrepancy of ADC measurement can substantially cause difficulty in cross-sectional or longitudinal liver DW-EPI. A preliminary study reported that a free-breathing liver DW-Propeller-EPI technique can provide superior image quality to conventional liver DW-EPI methods. In this study, we further improved the robustness of free-breathing liver DW-Propeller-EPI by incorporating velocity-compensation (VC) diffusion gradient into data acquisition, and then evaluated the repeatability of liver ADC measurement for free-breathing DW-Propeller-EPI by comparing to three routine liver DW-EPI methods.

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