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Abstract #0319

Characterization of Arterial and Portal Venous Contributions to Metabolic Imaging of the Human Liver Using Hyperpolarized 13C-pyruvate MRI

Philip Meng-en Lee1, Jeremy W Gordon1, Zhen J Wang1, Zihan Zhu1, Hsin-Yu Chen1, Pamela N Munster2, Rahul Aggarwal2, Daniel B Vigneron1, and Michael A Ohliger1
1Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Department of Medicine, University of California, San Francisco, San Francisco, CA, United States

Analysis of the delivery and metabolism of hyperpolarized 13C pyruvate within the liver is complicated by the organ’s unique dual blood supply. Distinguishing the hepatic arterial and portal venous contributions of pyruvate delivery would improve real-time acquisition triggering and kinetic modeling. Three healthy subjects and two metastatic cancer subjects underwent hyperpolarized 13C MRI on a clinical 3 T MR scanner. We observed differential arrival of [1-13C]pyruvate signal in the aorta, inferior vena cava, portal vein, healthy liver, and metastases matching physiologic expectations. Consistencies were observed within subject groups, which is crucial for accurate timing and modelling of metabolic hyperpolarized signals.

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