Abstract #0319

Characterization of Arterial and Portal Venous Contributions to Metabolic Imaging of the Human Liver Using Hyperpolarized 13C-pyruvate MRI

Philip Meng-en Lee¹, Jeremy W Gordon¹, Zhen J Wang¹, Zihan Zhu¹, Hsin-Yu Chen¹, Pamela N Munster², Rahul Aggarwal², Daniel B Vigneron¹, and Michael A Ohliger¹

¹Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Medicine, University of California, San Francisco, San Francisco, CA, United States

Analysis of the delivery and metabolism of hyperpolarized ¹³C pyruvate within the liver is complicated by the organ’s unique dual blood supply. Distinguishing the hepatic arterial and portal venous contributions of pyruvate delivery would improve real-time acquisition triggering and kinetic modeling. Three healthy subjects and two metastatic cancer subjects underwent hyperpolarized ¹³C MRI on a clinical 3 T MR scanner. We observed differential arrival of [1-¹³C]pyruvate signal in the aorta, inferior vena cava, portal vein, healthy liver, and metastases matching physiologic expectations. Consistencies were observed within subject groups, which is crucial for accurate timing and modelling of metabolic hyperpolarized signals.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.