Abstract #0321

Cortical ß-amyloid plaque load detection using QSM in Alzheimer’s patients at 9.4T

Elisa Tuzzi^1,2, Rolf Pohmann³, Alexander Loktyushin³, Christoph Laske^4,5, Klaus Scheffler^3,6, and Gisela Elisabeth Hagberg^3,6

¹Department for Biomedical Magnetic Resonance, Eberhard Karl’s University and University Hospital, Tuebingen, Germany, ²Department for High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetic, Tuebingen, Germany, ³Department for High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ⁴German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany, ⁵Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, Tuebingen, Germany, ⁶Department for Biomedical Magnetic Resonance, Eberhard Karl’s University, Tuebingen and University Hospital, Tuebingen, Germany

Beta-amyloid (Aβ) plaques are characteristic of Alzheimer’s Disease (AD) brain and cause effects which can be detected by QSM. It has been shown that cortical plaque-load could be used to distinguish AD patients from healthy controls (HC) using ultra-high spatial resolution QSM at ultra-high-field (9.4 and 14.1T), in-vivo and ex-vivo. We aimed to extend these observations to a larger cohort of patients and controls at two different spatial resolutions. We found a significative (p<0.05) increase in plaque-load in AD compared to HC at both resolutions. Interestingly, some cortical regions also showed greater (p<0.05) diamagnetic effects in AD compared to HC.

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