Abstract #0322

Iron deposits estimated by QSM MRI: a biomarker of depressive symptoms in cognitively normal and impaired adults with vascular problems

Sandeepa Sur^1,2, Lin Chen¹, Danyang Yu³, Leah H Rubin^2,4, Yanxun H Xu⁵, Zixuan Lu¹, Sevil Yasar⁶, Paul Rosenberg⁷, Rita Kalyani⁶, Kaisha H HAzel¹, George H Pottanat⁸, Peter van Zijl⁹, Marilyn Albert², Hanzhang Lu¹, and Xu Li⁹

¹Radiology, Johns Hopkins University, Baltimore, MD, United States, ²Neurology, Johns Hopkins University, Baltimore, MD, United States, ³Engineering, Johns Hopkins University, Baltimore, MD, United States, ⁴Epidemiology, Johns Hopkins University, Baltimore, MD, United States, ⁵Whitting School of Engineering, Johns Hopkins University, Baltimore, MD, United States, ⁶Medicine, Johns Hopkins University, Baltimore, MD, United States, ⁷Psychiatry and Behavorial Sciences, Johns Hopkins University, Baltimore, MD, United States, ⁸Johns Hopkins University, Baltimore, MD, United States, ⁹Kirby Center, Kennedy Krieger Institute, Baltimore, MD, United States

This study explored whether brain iron deposits in gray matter, measured as increased magnetic susceptibility, is a good biomarker for depressive symptoms in older adults with normal and impaired cognition, and vascular comorbidities. In a cross-sectional study(n=73) of normal, mild-cognitive-impairment (MCI), and mild-dementia participants with vascular comorbidities, increased susceptibility in brain-regions (frontal, temporal, parietal, occipital, hippocampus and thalamus) was associated with depressive symptoms (Geriatric Depression Scale, GDS) after adjusting for age, sex, diagnosis, and structural-volume loss, suggesting its potential use as biomarker for depressive symptoms in normal and impaired older adults.

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