Here, we examine brain white matter diffusion magnetic resonance imaging data from a mixed longitudinal and cross-sectional dataset of 892 subjects and 1991 sessions of people aged 22.4-102.0 years from the Baltimore Longitudinal Study of Aging. Quantifying 7 microstructural features and, for the first time, 11 shape-based features across 49 white matter pathways, we document large age associations with white matter. Microstructure and shape measures are associated with age, although features of white matter shape do not show uniform trends across all pathways. Results from this study provide a comprehensive characterization of white matter pathways in the human brain.
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