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Abstract #0324

White matter shape and microstructure across the adult lifespan

Kurt G Schilling1, Fang-Cheng Yeh2, Leon Cai3, Colin Hansen3, Qi Yang3, Andrea T Shafer4, Susan Resnick4, Adam W Anderson3, and Bennett A Landman3
1Vanderbilt University Medical Center, Nashville, TN, United States, 2University of Pittsburgh Medical Center, Pittsburgh, PA, United States, 3Vanderbilt University, Nashville, TN, United States, 4National Institute on Aging, Baltimore, MD, United States

Here, we examine brain white matter diffusion magnetic resonance imaging data from a mixed longitudinal and cross-sectional dataset of 892 subjects and 1991 sessions of people aged 22.4-102.0 years from the Baltimore Longitudinal Study of Aging. Quantifying 7 microstructural features and, for the first time, 11 shape-based features across 49 white matter pathways, we document large age associations with white matter. Microstructure and shape measures are associated with age, although features of white matter shape do not show uniform trends across all pathways. Results from this study provide a comprehensive characterization of white matter pathways in the human brain.

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