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Abstract #0325

Alterations of Structural-Functional Coupling in Amyloid-Positive and Negative Mild Cognitive Impairment Patients

Hui Zhang1,2, Sai Kam Hui3, Peng Cao1, and Henry K.F. Mak1,2,4
1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2Alzheimer's Disease Research Network, The University of Hong Kong, Hong Kong, Hong Kong, 3Department of Rehabilitation Science, The Hong Kong Polytechnic University, Hong Kong, Hong Kong, 4State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, Hong Kong

To identify the structural and functional abnormalities in mild cognitive impairment (MCI) amyloid positive patients, combined resting state fMRI (rs-fMRI) and diffusion kurtosis imaging (DKI) were applied in this study. Graph theory metrics of subgroups were calculated and compared. In the results, MCI amyloid positive had impaired structural connectivity (SC) but not functional connectivity (FC) matrices and demonstrated significant SC-FC decoupling. We postulated that structural damage preceded functional reorganization. The pathological effects of fibrillar amyloid plaque toxicity occur in anatomical pathways, and functional reorganization might happen beyond the confines of structural pathways.

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