To identify the structural and functional abnormalities in mild cognitive impairment (MCI) amyloid positive patients, combined resting state fMRI (rs-fMRI) and diffusion kurtosis imaging (DKI) were applied in this study. Graph theory metrics of subgroups were calculated and compared. In the results, MCI amyloid positive had impaired structural connectivity (SC) but not functional connectivity (FC) matrices and demonstrated significant SC-FC decoupling. We postulated that structural damage preceded functional reorganization. The pathological effects of fibrillar amyloid plaque toxicity occur in anatomical pathways, and functional reorganization might happen beyond the confines of structural pathways.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords