Diffusion-weighted MRSI (DW-MRSI) promises to significantly expand the capability of in vivo tissue microstructural imaging by simultaneously measuring the diffusion properties of several molecules other than water. However, the applications of DW-MRSI have been mostly limited to either single voxels or 2D experiments with very low resolutions due to several fundamental technical challenges. We describe here a novel method to achieve 3D DW-MRSI with an unprecedented combination of speed, resolution and SNR, by synergizing a special fast sequence and subspace-based processing. We successfully demonstrated high-SNR DW-MRSI of the brain and metabolite-specific ADC maps with the highest ever resolution (3.4×3.4×5.3 mm3).
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