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Abstract #0338

3D-CRT-FID-MRSI in the brain at 7T: Evaluation of regional concentration estimates

Gilbert Hangel1,2, Benjamin Spurny3, Philipp Lazen2, Cornelius Cadrien1,2, Sukrit Sharma2, Zoe Käfer2, Nikolaus Doblinger2, Lukas Hingerl2, Eva Hečková2, Bernhard Strasser2, Stanislav Motyka2, Alexandra Lipka2, Stephan Gruber2, Christoph Brandner4, Rupert Lanzenberger3, Karl Rössler1, Siegfried Trattnig2,5, and Wolfgang Bogner2
1Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, 2High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 3Division of General Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria, 4High Field MR Centre, Centre for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 5Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

Applying a 3D-MRSI sequence with ~3 mm isotropic resolution and 15 min measurement time at 7T to a cohort of 24 healthy subjects, we successfully estimated the concentrations of 13 brain metabolites in 44 regions using internal water referencing. We established inter-subject coefficients of variation in the range of 10-20%. The resulting concentration estimates corresponded well to previous research except for GSH.

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