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Abstract #0339

Simultaneous Detection of Metabolite Concentration Changes, Water BOLD Signal and pH Changes during Visual Stimulation in the Human Brain at 9.4T

Johanna Dorst1, Tamas Borbath1, and Anke Henning1,2
1High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

Previous studies investigated relationships between the BOLD signal and metabolite concentration changes during visual stimulation by sequential or interleaved fMRI/fMRS measurements. The purpose of this study was to simultaneously investigate the dynamics of BOLD signal and metabolite levels in the activated human brain at 9.4T using the metabolite-cycling (MC) technique. A correlation between the MC water dynamics and concentration increases of lactate and glutamate during activation could be verified. Besides, it could be shown that the high spectral quality of fMRS at 9.4T facilitates separate fitting of creatine and phosphocreatine thereby enabling the calculation of pH dynamics during visual stimulation.

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