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Abstract #0340

In Vivo Measurement of 13C Labeling of Glutamate and Glutamine in the Human Brain Using 1H MRS

Li An1, Shizhe Li1, Maria Ferraris Araneta1, Milalynn Victorino1, Christopher Johnson1, and Jun Shen1
1National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States

A recently developed single-step spectral editing 1H MRS technique that induces intense Glu and Gln H4 singlets at TE = 56 ms was used to measure fractional enrichments of glutamate and glutamine in the dorsal anterior cingulate cortex (dACC) of five healthy volunteers after oral administration of [U-13C]glucose. This technique offers the ability to measure glutamate neurotransmission in the human brain with the high sensitivity and spatial resolution of 1H MRS using standard commercial equipment.

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