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Abstract #0343

Validation of dynamic Deuterium Metabolic Imaging (DMI) for the measurement of cerebral metabolic rates of glucose in rat.

Claudius Sebastian Mathy1,2,3, Monique A. Thomas1, Graeme F. Mason1,4,5, Robin A. de Graaf1,5, and Henk M. De Feyter1
1Department of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University, New Haven, CT, United States, 2Institute of Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany, 3Department of Diagnostic and Interventional Radiology, RWTH Aachen, Aachen, Germany, 4Department of Psychiatry, Yale University, New Haven, CT, United States, 5Department of Biomedical Engineering, Yale University, New Haven, CT, United States

Deuterium metabolic imaging (DMI) is a novel metabolic imaging technique where 2H MRSI is combined with administration of 2H-labeled substrates. DMI data acquired at metabolic steady-state reveal the relative activities of metabolic pathways, whereas dynamically acquired DMI also provides the metabolic pathway activity rates. The analysis of dynamic DMI data is complicated by the presence of deuterium label loss between deuterated products and water. Here we validated metabolic rates obtained with dynamic DMI with those established using more traditional, 13C-based MR methods.

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