Abstract #0343

Validation of dynamic Deuterium Metabolic Imaging (DMI) for the measurement of cerebral metabolic rates of glucose in rat.

Claudius Sebastian Mathy^1,2,3, Monique A. Thomas¹, Graeme F. Mason^1,4,5, Robin A. de Graaf^1,5, and Henk M. De Feyter¹

¹Department of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University, New Haven, CT, United States, ²Institute of Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany, ³Department of Diagnostic and Interventional Radiology, RWTH Aachen, Aachen, Germany, ⁴Department of Psychiatry, Yale University, New Haven, CT, United States, ⁵Department of Biomedical Engineering, Yale University, New Haven, CT, United States

Deuterium metabolic imaging (DMI) is a novel metabolic imaging technique where ²H MRSI is combined with administration of ²H-labeled substrates. DMI data acquired at metabolic steady-state reveal the relative activities of metabolic pathways, whereas dynamically acquired DMI also provides the metabolic pathway activity rates. The analysis of dynamic DMI data is complicated by the presence of deuterium label loss between deuterated products and water. Here we validated metabolic rates obtained with dynamic DMI with those established using more traditional, ¹³C-based MR methods.

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