Here we present spectroscopic and chemical shift imaging data from the brains of healthy human subjects acquired using a novel method termed qMRS, which enables tracking of metabolic turnover with the inherent sensitivity of 1H MRS and widespread applicability using standard 1H-based clinical MRI scanners. We demonstrate the feasibility of using qMRS and its corollary chemical shift imaging technique (qCSI) to monitor the temporal and spatial dynamics of metabolite labelling in the human brain following oral consumption of deuterium-labeled glucose. Unlike the related technique of deuterium metabolic imaging (DMI), qMRS does not require implementation of multinuclear MR spectroscopy.
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