Abstract #0344

Combining 1H MRS and deuterium labeled glucose for mapping of neural metabolism in humans

Abigail T.J. Cember¹, Laurie J. Rich¹, Puneet Bagga¹, Neil E. Wilson², Ravi Prakash Reddy Nanga¹, Deepa Thakuri¹, Mark Elliott¹, Mitchell D. Schnall³, John A. Detre⁴, and Ravinder Reddy¹

¹Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Siemens Medical Solutions, USA, Malvern, PA, United States, ³Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ⁴Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

Here we present spectroscopic and chemical shift imaging data from the brains of healthy human subjects acquired using a novel method termed qMRS, which enables tracking of metabolic turnover with the inherent sensitivity of ¹H MRS and widespread applicability using standard ¹H-based clinical MRI scanners. We demonstrate the feasibility of using qMRS and its corollary chemical shift imaging technique (qCSI) to monitor the temporal and spatial dynamics of metabolite labelling in the human brain following oral consumption of deuterium-labeled glucose. Unlike the related technique of deuterium metabolic imaging (DMI), qMRS does not require implementation of multinuclear MR spectroscopy.

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