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Abstract #0345

The Macromolecular Background Spectrum Does Not Change with Age in Healthy Participants

Steve C.N. Hui1,2, Tao Gong3, Helge J. Zöllner1,2, Yulu Song3, Yufan Chen3, Muhammad G. Saleh4, Mark Mikkelsen1,2, Georg Oeltzschner1,2, Sofie Tapper1,2, Weibo Chen5, Richard A.E. Edden1,2, and Guangbin Wang3
1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Imaging and Nuclear Medicine, Shandong Medical Imaging Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China, 4Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 5Philips Healthcare, Shanghai, China

The aim of this project was to investigate the time course of macromolecular (MM) background spectrum during healthy aging. Recruiting a structured, cross-sectional cohort of 100 participants (10 male and 10 female subject per decade: 20s; 30s; 40s; 50s; and 60s), we acquired metabolite-nulled short-TE PRESS data and modeled the MM spectrum as a series of Gaussian signals at literature-defined chemical shifts. Linear regression of water-scaled MM signal areas revealed no significant relationship between age and MM signal areas, suggesting the MM spectrum may be more stable than has been suggested in the literature.

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