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Abstract #0346

Ultra high-field, high-resolution, multi-voxel MRS in pre-manifest and early-manifest Huntington's DiseaseĀ 

Yan Li1, Huawei Liu1, Angela Jakary1, Sivakami Avadiappan1, Melanie Morrison1, Ralph Noeske2, Peder E.Z. Larson1, Alexandra Nelson3, Katherine Possin3, Michael Geschwind3, Christopher Hess1, and Janine M Lupo1
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2GE Healthcare, Munich, Germany, 3Department of Neurology, University of California San Francisco, San Francisco, CA, United States

In this study of Huntington's Disease (HD), we evaluated brain metabolites from pre-manifest HD (PM) and early-manifest HD (EM), as well as their relationship to disease burden and motor disturbances. We used multi-voxel MRS at ultra-high field strength (7T), in order to improve the reliability and sensitivity of detecting focal metabolic changes that are related to HD. We found metabolic alterations in the thalamus and insula and changes in choline, mI, glutathione and glutamate that were correlated with clinical measures of disease severity.

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