Abstract #0350

Early Non-Contrast Biomarkers of Left Ventricular Cardiomyopathy in Children with Duchenne Muscular Dystrophy

ZHAN-QIU LIU¹, Nyasha Maforo², Seraina Dual³, Ashley Prosper⁴, Pierangelo Renella⁴, Nancy Halnon⁵, Holden Wu⁴, and Daniel Ennis³

¹Cardiovascular Institute, Stanford University, Stanford, CA, United States, ²Physics and Biology in Medicine Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, United States, ³Department of Radiology, Stanford University, Stanford, CA, United States, ⁴Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ⁵Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States

Left ventricular(LV) peak mid-wall circumferential strain (Ecc) is a sensitive early biomarker for evaluating the subtle and highly variable onset and progression of cardiomyopathy in pediatric subjects with Duchenne muscular dystrophy (DMD). Cine Displacement Encoding with Stimulated Echoes (DENSE) has proven sensitive to changes in Ecc. Using cine DENSE we show a significantly decreased septal Ecc in LGE negative(-) boys with DMD absent identifiable focal fibrosis compared with controls. A binomial logistic regression model that combines septal Ecc, LV pre-contrast T1, and LV ejection fraction can sensitively distinguish LGE(-) boys with DMD from healthy boys without the need for contrast.

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