Abstract #0351

Evaluating the Risk of Pediatric Neuroblastoma in the Abdomen with Amide Proton Transfer Imaging

Wenqi Wang¹, Xuan Jia², Jiawei Liang², Xiaohui Ma², Weibo Chen³, Dan Wu¹, Can Lai², and Yi Zhang¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China, ²Department of Radiology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, ³Philips Healthcare, Shanghai, China

Neuroblastoma (NB) most often occurs in young children, and accurate diagnosis of NB with anatomical MRI remains challenging. Here, we explored the potential of amide proton transfer (APT) imaging in evaluating the risk of pediatric abdominal NB. A total of 25 patients were enrolled, including 12 with low-risk NB and 13 with high-risk NB. An automatic shrinkage algorithm was applied to the initial region of interest delineated by an experienced radiologist to focus on the most aggressive part of tumors. We obtained an AUC of 0.917 for stratifying the risk of NB with APT, demonstrating the potential of clinical application.

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