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Abstract #0352

Liver Stiffness in a Single Breath-hold Using Wave Polarity-Inversion Motion Encoding and Compressed SENSE: Coverage Equivalent to 5 Slices

Amol Pednekar1, Deep B. Gandhi2, Hui Wang3, Jean A. Tkach1, Andrew T. Trout1, and Jonathan R. Dillman1
1Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 3MR Clinical Science, Philips, Cincinnati, OH, United States

2D GRE MRE liver images acquired at 4 transverse levels in breath-hold times >13s per slice is currently standard of care (SC_2D_4BH). The combination of wave polarity-inversion motion encoding and compressed-SENSE enables volumetric three-dimensional (3D) MRE data acquisition in a single breath-hold of <16 s, with identical spatial resolution and 5 slice equivalent coverage (3D_5Sl_SBH). In 19 participants, mean liver shear stiffness values estimated with SC_2D_4BH and 3D_5sl_SBH correlated very strongly (ICC=0.96) with a mean bias of 0.13 kPa (<5 %). 3D_5sl_SBH MRE provides similar stiffness estimates as SC_2D_4BH with increased coverage in a single breath-hold compared to 4 breath-holds.

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