Abstract #0355

Regional changes in brain development and cognitive outcome in infants with Congenital Heart Disease

Alexandra F Bonthrone¹, Ralica Dimitrova^1,2, Andrew Chew¹, Christopher J Kelly¹, Lucilio Cordero-Grande^1,3, Olivia Carney¹, Alexia Egloff¹, Emer Hughes¹, Katy Vecchiato^1,2, John Simpson⁴, Joseph V Hajnal^1,5, Kuberan Pushparajah⁴, Suresh Victor¹, Chiara Nosarti^1,6, Mary A Rutherford¹, A. David Edwards¹, Jonathan O’Muircheartaigh^1,2, and Serena J Counsell¹

¹Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom, ³Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid and CIBER-BBN, Madrid, Spain, ⁴Paediatric Cardiology Department, Evelina London Children's Healthcare, London, United Kingdom, ⁵Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁶Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom

Infants with Congenital Heart Disease (CHD) are at high risk of neurodevelopmental disorders. We acquired presurgical neonatal T2-weighted MRI (N=66), cerebral oxygen delivery (CDO₂; N=53), and 22-month cognitive and motor scores (N=44). Atypicality indices, representing the degree of deviation of a regional brain volume from the normative neonatal mean for a given gestational age, sex and postnatal age, were calculated. Reduced CDO₂ was indirectly associated with lower cognitive scores through the mediating effect of negative bilateral caudate and thalami atypicality indices. The aetiology of cognitive impairments in CHD may encompass poor CDO₂ leading to impaired caudate and thalamus growth.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.