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Abstract #0356

Transcriptomic decoding of the human brain structural connectome through the 3rd trimester and early childhood

Chenying Zhao1,2, Gabriel Santpere3, Minhui Ouyang1, David Andrijevic4, Nenad Sestan4, and Hao Huang1,5
1Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States, 3Neurogenomics group, Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), DCEXS, Universitat Pompeu Fabra, Barcelona, Spain, 4Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, United States, 5Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Transcriptome, the set of gene expression, is spatiotemporally heterogeneous across brain development. Under its regulation, dramatic changes in brain connectivity estimated through diffusion MRI is observed in early childhood. However, the association between the macroscopic structural connectome and microscopic transcriptome across early postnatal years is not clear. Here, we revealed this dynamic association between structural connectome and gene expression from a large cohort of 200 neonates and children through the 3rd trimester and early childhood. The changes of associated genes’ enrichment in cell types and biological processes across different ages shed light into the dynamic transcriptomic roles in connectome development.

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