Abstract #0368

Hyperpolarized 13C Metabolic Imaging of Patients with Pancreatic Ductal Adenocarcinoma

Jeremy W Gordon¹, Hsin-Yu Chen¹, Philip Lee¹, Robert Bok¹, Michael Ohliger¹, Andrew Ko², Eric Collisson², Margaret Tempero², Pelin Cinar², Peder Larson^1,3, and Zhen Jane Wang^1,3

¹Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Medicine, University of California, San Francisco, San Francisco, CA, United States, ³UC Berkeley-UCSF Graduate Program in Bioengineering, San Francisco, CA, United States

Metabolic imaging of hyperpolarized [1-¹³C]pyruvate was performed in four patients with pancreatic ductal adenocarcinoma prior to chemotherapy. Compared to the normal appearing pancreas, higher lactate/pyruvate and lower alanine/pyruvate ratios were seen in the primary tumors. The alanine/lactate ratio, which reflects the relative enzymatic activity and metabolite pool sizes, was reduced 2- to 20-fold in the tumors and provided improved contrast between tumor and normal appearing pancreas over either the lactate/pyruvate or alanine/pyruvate ratio. These results indicate the potential for HP ¹³C MRI to be a novel tool to stage disease and assess treatment response in pancreatic cancer patients

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