We evaluated the efficacy of a zoomed diffusion-weighted echo-planar imaging (z-EPI) sequence to diagnose periampullary carcinoma compared with a conventional single-shot EPI (c-EPI) sequence. Better delineation of lesion conspicuities and margins were observed, as well as enhanced diagnostic confidence with z-EPI. The diagnostic accuracy increased by combining magnetic resonance cholangiopancreatography (MRCP) and z-EPI together. These findings showed remarkable image quality improvements for periampullary carcinomas using z-EPI. The ability to detect and delineate lesions using z-EPI was superior to that of c-EPI. Diagnostic accuracy was also attained, especially for small lesions.
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