Abstract #0377

Blood-CSF Barrier Imaging in the Human Brain with Arterial Spin Labeling

Leonie Petitclerc^1,2, Lydiane Hirschler¹, Jack A. Wells³, David L. Thomas^4,5,6, and Matthias J.P. van Osch^1,2

¹C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden Institute for Brain and Cognition (LIBC), Leiden, Netherlands, ³UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom, ⁴Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ⁵Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ⁶Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom

In order to measure the function of the blood-CSF barrier (BCSFB), a modified ASL experiment is introduced. This is accomplished with multiple time-points, including long labeling duration and post-labeling delay, and an echo train of 8 TEs from 10-1837ms. Long-T2 ASL signal, attributable to the CSF, was found both in the choroid plexus and around the cortex. Fitting of this signal to two models (a simple triexponential and a dynamic compartmental model) reveals an amount of CSF signal about 5 times lower than the perfusion. The transfer time of water across the BCSFB is estimated at around 100s.

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