Abstract #0383

The association of intracranial arterial pulsatility with enlarged perivascular spaces

M. van den Kerkhof^1,2, M.M. van der Thiel^1,2, I.H.G.B. Ramakers^2,3, R.J. van Oostenbrugge^2,4,5, A.A. Postma¹, A.A. Kroon^5,6, J.F.A. Jansen^1,2,7, and W.H. Backes^1,2,5

¹Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ²School for Mental Health & Neuroscience, Maastricht University, Maastricht, Netherlands, ³Department of Psychiatry & Neuropsychology, Maastricht University, Maastricht, Netherlands, ⁴Department of Neurology, Maastricht University Medical Center, Maastricht, Netherlands, ⁵School for Cardiovascular Disease, Maastricht University, Maastricht, Netherlands, ⁶Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ⁷Department of Electrical Engineering, Eindhoven University of Technology, Maastricht, Netherlands

Intracranial vessel wall alterations may lead to an increased blood flow pulsatility and the enlargement of perivascular spaces (ePVS). To examine the relationship between these measures, this 7T MRI study applied phase contrast MRI to measure blood flow velocity in the middle cerebral artery and lenticulostriate arteries (LSAs) and obtained ePVS visual rating scores. An increased LSA pulsatility index was found to be related to a higher number of ePVS in the basal ganglia and centrum semiovale. These findings are in support of underlying alterations of the cerebral small vessel wall, which influence both the ePVS and the pulsatility.

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